Fully Initiate INVEGA SUSTENNA® for Schizophrenia in 7 Days With 2 Initiation Doses—With No Oral Supplementation1


  • Both initiation doses must be given in the deltoid muscle1
  • For patients who have not taken oral paliperidone, oral risperidone, or injectable risperidone, establish tolerability first1
  • Previous oral antipsychotics can be discontinued at the time of initiation of treatment with INVEGA SUSTENNA®1
  • To avoid a missed dose, patients may be given the second initiation dose within a ±4-day flexible window1

Monthly Maintenance Doses

The first monthly maintenance dose* should be administered 5 weeks after the first injection (regardless of the timing of the second injection)1

initiation dosage
  • To avoid a missed dose, monthly maintenance doses may be given within a ±7-day flexible window1
  • Utilizing the maintenance dosing window to help avoid missed doses should be considered the exception rather than the rule

*The recommended maintenance dose for the treatment of schizophrenia is 117 mg. Patients may benefit from flexible maintenance dosing options within the available strengths.

Administration notes1

  • Each injection must be administered by a healthcare professional
  • Select the appropriate needle size depending on the patient’s weight and injection location
  • Shake the prefilled syringe for at least 10 seconds before administering
Dosing Guide

Download the full Dosing and Administration Guide


Reference: 1. INVEGA SUSTENNA® [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; August 2021.