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Prolactin data observed were similar between INVEGA HAFYERA® and INVEGA TRINZA®1
Percentage of patients in the pivotal study with increased prolactin levels relative to maintenance baseline
Like other drugs that antagonize dopamine D2 receptors, paliperidone elevates prolactin levels, and the elevation persists during chronic administration. Paliperidone has a prolactin-elevating effect similar to that seen with risperidone, a drug that is associated with higher levels of prolactin than other antipsychotic drugs.
Percentage of patients in the pivotal study with potentially prolactin-related adverse reactions
Reference: 1. INVEGA HAFYERA® [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.